Running 10.7.4 right now and almost everything works (i7 920, GTX 260, MBR Dual Boot, no RAID). Just asking because I ran into a lot of work and need a stable system. Can't stop thinking of Mountain Lion though, there just too many nice features
for me i would say yes. similar system although my boot disk is guid partition not mbr. The biggest problem i had was graphics, chameleon injection wouldn't work anymore, so i extracted my device properties form lion, and injected that via the boot plist. apart form that, my same DSDT works right from leopard. I use a DSDT that works with native apple audio kexts, if you don't then you may need to find the right custom/patched kext to work for you.
also see above about optical drive.
I did a clean install and migrated user files, but re-installed apps manually, i always find that the safest.