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Well, I have some experience on running Metal Gear Solid 2 Substance on my mac. There is two ways I've found: 1st and most obvious - Install Win XP through BootCamp 2nd - run on virtual machine in Mac OS X First method I think don't need to explain, so I will tell about second... You need vmWare Fusion 3.1.3 and original MGS2 with No-DVD + copy of Windows XP Basically installation of Windows through vmWare is very simple and quick so you won't have a problem, Then in Virtual Machine install your MGS2 On my mac it was working pretty fast but small issues with textures Note that it will work only with vmWare, Parallels won't give you any picture when you will try to execute this... Hope you find it helpful, Cheers! PS I didn't try any of numerous patches for MGS2 so maybe you can try to eliminate all issues by yourself