I plan on having two water cooling loops, but there is not enough space to have the radiators in separate locations in the case. I am wondering if setting up the rads and fans together will get efficient cooling. I plan on setting it up Fan/Rad/Rad/Fan with one of the rads nozzles on top and the others on the bottom. Will this work?

How about putting another row of fans between the rads Fan/Rad/Fan/Rad/Fan? How hard is it to push air through a 60mm thick rad?