Don't be a chicken ! Experiment ! That's the way to learn new things. In the worst case scenario (assuming you are using the wiki to choose a supported card ) you will get a vesa unaccelerated image and wrong resolution untill you find and install the proper drivers , but OS x will still load. In any case you will still have the old videocard around to put it back in the unlikely event you will get a blank screen.
Don't worry so much , it's not heart surgery

Marius