Hi
I use ideneb 10.5.8 with vanilla.
I´ve a digidesign mbox 2 mini and rme hdsp 9632 pci.
I work with logic 9 & Protools without problems. Good midi timing, great audio behaivor, no issues at all.
Is the best way to make music on a normal pc because XP or vista is a nightmare.

Bad midi timing...
You must know a little bit of your components and see if this have compatibility with osx86.
This matters take a big time and effort but when your system work..... yeahhhhhhhh
Take your time to read in this incredible forum, a lot of good people can help you.
Good luck
Jordi