I have my MBox2Mini working with iTunes and Quicktime so far on the following system:
Q9300, ASUS P5E, ASUS 8800GT 512, Seagate 250GB System Drive, Kalyway 10.5.2 install, dual boot with XP

You will require the old "Tiger" set of drivers that you can download from your "My Digi" downloads section.

If you don't have a "My Digi" account you can try this SpeedyShare link:
http://www.speedyshare.com/272442854.html

I will be purchasing Logic tomorrow so I will report back on how successful it goes.